OSTHOLE ALLEVIATES NEOINTIMAL HYPERPLASIA IN BALLOON-INDUCED ARTERIAL WALL INJURY BY SUPPRESSING VASCULAR SMOOTH MUSCLE CELL PROLIFERATION AND DOWNREGULATING CYCLIN D1/CDK4 AND CYCLIN E1/CDK2 EXPRESSION

Percutaneous coronary intervention (PCI) is the most widely used therapy for treating ischemic heart disease.However, intimal hyperplasia and restenosis usually occur within months after angioplasty.Modern pharmacological researchers BRAIN FUNCTION have proven that osthole, the major active coumarin of Cnidium monnieri (L.) Cusson, exerts potent an

Background The role of CD161 expression on CD8+ T cells in tumor immunology has been explored in a few studies, and the clinical significance of CD161+CD8+ T cells in pancreatic ductal adenocarcinoma (PDAC) remains unclear.This study seeks to clarify the prognostic value and molecular characteristics linked to CD161+CD8+ T cell infiltration in PDAC

Nemerteans (ribbon worms) employ toxins to subdue their prey, but research thus far has focused on the small-molecule components of mucus secretions and Patio Dining Chair few protein toxins have been characterized.We carried out a preliminary proteotranscriptomic analysis of putative toxins produced by the hoplonemertean Amphiporus lactifloreus (H

The widespread, and in many countries unprecedented, use of non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic has highlighted the need for mathematical models which can estimate the impact of these measures while accounting for the highly heterogeneous risk profile of COVID-19.Models accounting either for age structure or the hou

Mycoplasma pneumoniae is a common organism responsible for pediatric community-acquired pneumonia.Extrapulmonary complications including thrombosis, although rare, are known to be associated with severe M.pneumoniae pneumonia.We report the case of left atrial thrombus extending into right inferior pulmonary vein in Glue Sticks a child with severe M